Cytiva® MabSelect™

MabSelect™ is a BioProcess affinity medium for capturing monoclonal antibodies (MAbs) from large sample volumes. MabSelect is developed for cost-effective high throughput processing of large amounts of feed. This is the reason why MabSelect has been designed-in to several new and second-generation processes for the production of therapeutic MAbs. The medium is based on a highly cross-linked agarose matrix with a recombinant protein A ligand. This ligand is engineered to favor an oriented coupling resulting in an affinity medium with enhanced binding capacity for IgG. The hydrophilic nature of the base matrix ensures low levels of non-specific binding leading to low levels of host cell-derived impurities in the elution pool. MabSelect is optimized for high capacity, throughput and to deliver a product pool that is high in purity and yield.