Chemically defined ADCF media for use with PER.C6 cells. HyClone CDM4PERMAb medium has a chemically defined and animal-derived component-free (ADCF) formulation. This high-performance cell culture medium has been developed to increase process yields in the production of human antibodies and recombinant proteins using PER.C6 technology. The medium has been successfully tested in a variety of applications, including fed-batch bioreactor cultures. CDM4PERMAb is available in liquid and powder formats in user-friendly packaging.