MabSelect PrismA™ X protein A resin is a high-capacity chromatography resin designed to efficiently capture monoclonal antibodies (mAbs). It features exceptional alkaline stability for repeated cleaning in place (CIP) to reduce bioburden. The resin is based on a highly cross-linked agarose base matrix with a median particle (bead) size d50v of 50 μm. The DBC for MabSelect PrismA™ X resin using trastuzumab is excellent. At 6 min, the DBC is 82 mg/mL for MabSelect PrismA™ X resin and 74 mg/mL for MabSelect PrismA™ resin. As the high DBC is realized at short RT, the MabSelect PrismA™ X resin is beneficial for use in RCC to further reduce resin volumes to increase grams of mAb produced per liter of resin and decrease overall resin costs.
