PG-006, a selective inhibitor of BMP4, is a novel functional cyclic peptide capable of selectively inhibiting the signaling of the BMP4 family (BMP2, BMP4). Together with PG-005, a BMP7 selective inhibitor, PG-006 and PG-005 enable the selective inhibition of BMP4 and BMP7 signaling, which was not possible with existing small kinase inhibitors or Noggin.

This peptide can be utilized for detailed analysis and control of BMP signaling, as well as for the construction of new cellular differentiation pathways. The molecular weight of PG-006 is 3301.59 (acetate), and it exhibits comparable inhibitory activity against the BMP4 family to Noggin on a molar basis.